AN UNBIASED VIEW OF PKRRATING

The activated enzyme then read more phosphorylates its important substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to your conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to different stimuli12, triggering the